Launched in 2022 by the Lung Analysis Lab at Erasmus MC, the ENRICH project is set up to significantly strengthen the clinical value of the ECFS Patient Registry (including data of 54,000 patients) by introducing a standardized and validated method to quantify structural lung abnormalities from chest CT. It is the first-ever initiative to integrate AI-powered imaging outcome analysis into the European Cystic Fibrosis Society (ECFS) Patient Registry (which contains data on 54,000 CF patients).
To analyze the study cohort, Thirona’s Bronchi-Arterial (LungQ® BA) and Mucus Plugs (LungQ® MP) metrics are used, providing detailed measurements of airway wall thickness, the total number and volume of mucus plugs, airway widening and narrowing on a segmental level.
Thirona is conducting quantitative analyses of structural lung abnormalities using selected metrics to monitor treatment efficacy and disease progression, and to identify prognostic factors.
“Quantifying lung abnormalities provides a crucial new capability for the registry, allowing us to integrate essential data on structural lung damage – particularly when working with such a large patient cohort. Manual analysis at this scale isn’t feasible, but automated tools make it both possible and reliable.”
Dr. Daan Caudri | Director of LungAnalysis Lab and Assistant Professor, Erasmus MC
