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European initiative to standardize QCT metrics in CF population data

Launched in 2022 by the Lung Analysis Lab at Erasmus MC, the ENRICH project is set up to significantly strengthen the clinical value of the ECFS Patient Registry (including data of 54,000 patients) by introducing a standardized and validated method to quantify structural lung abnormalities from chest CT. It is the first-ever initiative to integrate AI-powered imaging outcome analysis into the European Cystic Fibrosis Society (ECFS) Patient Registry (which contains data on 54,000 CF patients).  

LungAnalysis of Erasmus Medical Center
European Cystic Fibrosis Society Patient Registry
Erasmus Medical Center in Rotterdam, Netherlands

Project highlights

  • Oct 2022 – ENRICH project launch
  • Sep 2025 – Preliminary results to be presented at the ERS Congress
  • Oct 2026 – Expected end of the project

Contribution by Thirona

Thirona is conducting quantitative analyses of structural lung abnormalities using selected metrics to monitor treatment efficacy and disease progression, and to identify prognostic factors. 

  • LungQ® BA: For precise quantification of bronchial wall thickness and bronchus-to-artery ratios. 
  • LungQ® MP: For quantification of mucus plug volume and count. 
  • LungQ® VERA: For air trapping assessment 
“Quantifying lung abnormalities provides a crucial new capability for the registry, allowing us to integrate essential data on structural lung damage – particularly when working with such a large patient cohort. Manual analysis at this scale isn’t feasible, but automated tools make it both possible and reliable.” 
Dr. Daan Caudri | Director of LungAnalysis Lab and Assistant Professor, Erasmus MC

Relevant Publications

| November 2025

Quality of CT based airway segmentation software for navigation bronchoscopy

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BMC Pulmonary Medicine

| October 2025

Fibrotic and vascular abnormalities quantified by an AI-based model are associated with outcomes in patients with idiopathic pulmonary fibrosis

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The Lancet Respiratory Medicine

| October 2025

Effect of elexacaftor–tezacaftor–ivacaftor on bronchial dilatations in adolescents with cystic fibrosis: a multicentre prospective observational study

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Research Square

| October 2025

The impact of dornase alfa on imaging features of bronchiectasis

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BMJ Journals

| October 2025

Finding the optimal regimen for Mycobacteroides abscessus treatment (FORMaT) in people with Mycobacteroides abscessus pulmonary disease: a multicentre, randomised, multi-arm, adaptive platform trial

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ERJ Open Research

| August 2025

Automated computed tomographic analysis of bronchial thickness and mucus plugs in bronchiectasis with asthma

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